I’m still on the Off Topic series.
The context of this diary is primarily cellular. We’ve moved up a level of biological scale from the previous diary, Transition. Some may suggest that the molecular and cellular scales also define the non-living/living divide (if such a thing actually exists). That topic is beyond the scope of this diary. [Besides, I tend to piss off the philosophers when I talk about the meaning of life, so let’s get better acquainted before we tear the lid off that one.]
One of the minor mysteries in biophysical chemistry is how cells manage to elicit sudden changes in various metabolic and physiologic characteristics, traits, or phenotypes. These changes are in response to signals of fuel availability and physiological exigencies pertaining to the multi-cellular individual as implied by homeostasis. The cohort of human beings pondering these mysteries as a matter of career define the word “manage” in terms of macromolecular conformational changes, enzyme catalysis, and a wide range of interactions between macromolecules and with smaller molecules. The shorthand jargon term for this is mechanism. These are not new questions. They have bugged us ever since the first moving cells were observed.
The question becomes: How do cells organize the molecules within them in order to accomplish the functions that these have been observed to fulfill?
This discussion is in context of all the caveats this community can conjure.